드러그인포 약품요약정보 - 아이미루40이엑스점안액

허가정보

항목

내용

청구코드(KD코드)
비급여점검코드
상한금액

640002810 [보험코드에 따른 약품기본정보 직접조회]
[비급여]
[상병코드조회]
[질병코드집 다운로드] [우리집건강주치의 바로가기]

빠른조회


요약정보	[효능] [용법] [금기] [주의] [부작용]

상세정보	[효능] [용법] [경고] [금기] [신중] [부작용] [일반주의] [상호작용] [임산부] [수유부] [소아고령자] [적용] [과량투여] [임상검사치] [보관] [기타]

제품성상

특이한 냄새가 있는 무색의 맑은 액이 연두색 투명한 플라스틱 용기에 든 점안액 [제형정보 확인]

포장·유통단위

15mL/병

포장·코드단위

약품규격	단위	포장형태	대표코드	표준코드	비고
15밀리리터	1 개	병	8806400028109	8806400028116

주성분코드

B93700COS [동일한 주성분코드를 가진 오리지날 또는 제네릭 의약품 조회]

허가사항 원문조회

[조회]

효능효과

[적응증 별 검색]

눈의 피로, 결막충혈, 눈병예방(수영후 눈의 불쾌감 또는 먼지나 땀이 눈에 들어갔을 때), 자외선 및 기타광선에 의한 눈의 염증, 눈꺼풀의 짓무름, 하드콘택트렌즈를 착용시 불쾌감, 눈의 가려움, 눈의 침침함 (눈곱이 많을 때 등)

용법용량

* 절대 임의복용하지 마시고 반드시 의사 또는 약사와 상담하시기 바랍니다.

[처방약어]
1일 3~6회, 1회 1~3적 점안한다.

[BMI지수 계산] [Body Surface Area 계산] [Cockcroft-Gault GFR 계산] [MDRD GFR 계산]

금기

30개월 이하의 유아

주의

다음과 같은 사람은 이 약을 사용하기 전에 의사, 치과의사, 약사와 상의할 것.

1) 눈의 통증이 심한 환자

2) 지금까지 안약에 의한 알레르기(예를 들어 눈의 충혈, 가려움, 부종, 발진, 발적 등) 증상을 일으킨 적이 있는 환자본인 또는 가족이 알레르기 체질인 사람

3) 녹내장 환자

4) 의사의 치료를 받고 있는 환자

5) 소아 : 경련을 유발할 수 있다.

6) 소아에 투여할 경우에는 보호자의 지도, 감독하에 투여한다.

다음과 같은 경우 이 약의 사용을 즉각 중지하고 의사, 치과의사, 약사와 상의할 것.

1) 이 약의 투여에 의해 눈의 충혈, 가려움, 부종 및 피부의 발진, 발적, 가려움 등의 증상이 나타날 경우

2) 눈의 침침함이 개선되지 않는 경우

3) 5~6일간 투여 후에도 증상의 개선이 보이지 않는 경우

Off-label Usage

[조회]

Related FDA Approved Drug

기준 성분:CHLORPHENIRAMINE MALEATE
ADVIL ALLERGY SINUS (CHLORPHENIRAMINE MALEATE; IBUPROFEN; PSEUDOEPHEDRINE HYDROCHLORIDE)
ANTAGONATE (CHLORPHENIRAMINE MALEATE)
CHILDREN'S ADVIL ALLERGY SINUS (CHLORPHENIRAMINE MALEATE; IBUPROFEN; PSEUDOEPHEDRINE HYDROCHLORIDE)
CHLOROHENIRAMINE MALEATE AND PHENYLPROPANOLAMINE HYDROCHLORIDE (CHLORPHENIRAMINE MALEATE; PHENYLPROPANOLAMINE HYDROCHLORIDE)
CHLORPHENIRAMINE MALEATE (CHLORPHENIRAMINE MALEATE)
CHLORPHENIRAMINE MALEATE AND PHENYLPROPANOLAMINE HYDROCHLORIDE (CHLORPHENIRAMINE MALEATE; PHENYLPROPANOLAMINE HYDROCHLORIDE)
CHLOR-TRIMETON (CHLORPHENIRAMINE MALEATE)
CODIMAL-L.A. 12 (CHLORPHENIRAMINE MALEATE; PSEUDOEPHEDRINE HYDROCHLORIDE)
COLD CAPSULE IV (CHLORPHENIRAMINE MALEATE; PHENYLPROPANOLAMINE HYDROCHLORIDE)
COLD CAPSULE V (CHLORPHENIRAMINE MALEATE; PHENYLPROPANOLAMINE HYDROCHLORIDE)
CONTAC (CHLORPHENIRAMINE MALEATE; PHENYLPROPANOLAMINE HYDROCHLORIDE)
CONTAC 12 HOUR (CHLORPHENIRAMINE MALEATE; PHENYLPROPANOLAMINE HYDROCHLORIDE)
DEMAZIN (CHLORPHENIRAMINE MALEATE; PHENYLPROPANOLAMINE HYDROCHLORIDE)
DEXCHLORPHENIRAMINE MALEATE (DEXCHLORPHENIRAMINE MALEATE)
DRIZE (CHLORPHENIRAMINE MALEATE; PHENYLPROPANOLAMINE HYDROCHLORIDE)
EFIDAC 24 CHLORPHENIRAMINE MALEATE (CHLORPHENIRAMINE MALEATE)
ISOCLOR (CHLORPHENIRAMINE MALEATE; PSEUDOEPHEDRINE HYDROCHLORIDE)
KLOROMIN (CHLORPHENIRAMINE MALEATE)
ORNADE (CHLORPHENIRAMINE MALEATE; PHENYLPROPANOLAMINE HYDROCHLORIDE)
PHENETRON (CHLORPHENIRAMINE MALEATE)
PHENYLPROPANOLAMINE HYDROCHLORIDE W/ CHLORPHENIRAMINE MALEATE (CHLORPHENIRAMINE MALEATE; PHENYLPROPANOLAMINE HYDROCHLORIDE)
POLARAMINE (DEXCHLORPHENIRAMINE MALEATE)
PSEUDOEPHEDRINE HYDROCHLORIDE AND CHLORPHENIRAMINE MALEATE (CHLORPHENIRAMINE MALEATE; PSEUDOEPHEDRINE HYDROCHLORIDE)
PYRIDAMAL 100 (CHLORPHENIRAMINE MALEATE)
TELDRIN (CHLORPHENIRAMINE MALEATE)
TRIAMINIC-12 (CHLORPHENIRAMINE MALEATE; PHENYLPROPANOLAMINE HYDROCHLORIDE)

정보요약

드럭인포 의약품 요약/상세정보

코드 및 분류정보

항목	내용
주성분코드	B93700COS [동일한 주성분코드를 가진 오리지날 또는 제네릭 의약품 조회]
대표코드	8806400028109
BIT 약효분류	Eye steroids & antiallergics
ATC 코드	Artificial tears and other indifferent preparations / S01XA20 [코드분류상세설명] [ATC코드예측]
복지부분류코드	131 (안과용제 )
Drugs By Indication	[전체보기]
Drugs By Classification	[전체보기]

제품정보

항목	내용
청구코드(KD코드) 비급여점검코드 상한금액	640002810 [보험코드에 따른 약품기본정보 직접조회] [비급여] [상병코드조회] [질병코드집 다운로드] [우리집건강주치의 바로가기]
제품성상	특이한 냄새가 있는 무색의 맑은 액이 연두색 투명한 플라스틱 용기에 든 점안액 [제형정보 확인]
포장·유통단위	15mL/병
보관방법	기밀용기, 실온(1∼30℃)보관,
EZ-Drug 의약품정보검색	제품명:
지적재산권 정보조회	약품명으로 조회 • 아이미루40이엑스점안액 성분별 조회 • Chlorpheniramine Maleate • D-α-tocopherol Acetate • Neostigmine Methylsulfate • potassium L-Aspartate • Pyridoxine HCl • Retinol Palmitate • Tetrahydrozoline HCl 조회시 원하시는 정보를 못 찾으셨다면 여기에서 검색해 보시길 바랍니다.

복약정보

항목	내용
LACTmed 바로가기	[바로가기]
약리작용	유료정보입니다.
복약지도	유료정보입니다.
병용금기 및 연령대금기 근거조회	[병용금기 및 연령대금기 근거조회]
제형별 복약지도	[점안액]
보관상 주의
조제시 주의

심사정보

항목	내용
DUR 관련 고시	[병용연령금기 의약품] [임부금기 의약품] [저함량 배수처방 의약품] [안전성 관련 급여중지 의약품]

학술정보

항목	내용
DUR (의약품사용평가)	병용금기 : 고시된 병용금기 내용은 없습니다. [상호작용/병용금기검색] 연령대금기 : 고시된 연령금기 내용은 없습니다. [연령대금기상세검색]
독성정보	Chlorpheniramine에 대한 독성정보 : 정보보기 Pyridoxine에 대한 독성정보 : 정보보기 출처: 국립독성과학원 독성물질정보DB : http://www.nitr.go.kr/nitr/contents/m134200/view.do
Mechanism of Action	Chlorpheniramine에 대한 Mechanism_Of_Action 정보 Chlorpheniramine binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine. L-asparagine에 대한 Mechanism_Of_Action 정보 Asparagine, a non-essential amino acid is important in the metabolism of toxic ammonia in the body through the action of asparagine synthase which attaches ammonia to aspartic acid in an amidation reaction. Asparagine is also used as a structural component in many proteins. Neostigmine에 대한 Mechanism_Of_Action 정보 Neostigmine is a parasympathomimetic, specifically, a reversible cholinesterase inhibitor. By interfering with the breakdown of acetylcholine, neostigmine indirectly stimulates both nicotinic and muscarinic receptors. It does not cross the blood-brain barrier. Pyridoxine에 대한 Mechanism_Of_Action 정보 Vitamin B6 is the collective term for a group of three related compounds, pyridoxine (PN), pyridoxal (PL) and pyridoxamine (PM), and their phosphorylated derivatives, pyridoxine 5'-phosphate (PNP), pyridoxal 5'-phosphate (PLP) and pyridoxamine 5'-phosphate (PMP). Although all six of these compounds should technically be referred to as vitamin B6, the term vitamin B6 is commonly used interchangeably with just one of them, pyridoxine. Vitamin B6, principally in the form of the coenzyme pyridoxal 5'-phosphate, is involved in a wide range of biochemical reactions, including the metabolism of amino acids and glycogen, the synthesis of nucleic acids, hemogloblin, sphingomyelin and other sphingolipids, and the synthesis of the neurotransmitters serotonin, dopamine, norepinephrine and gamma-aminobutyric acid (GABA).
Pharmacology	Chlorpheniramine에 대한 Pharmacology 정보 In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once released, histamine can react with local or widespread tissues through histamine receptors. Histamine, acting on H₁-receptors, produces pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Chlorpheniramine, is a histamine H1 antagonist (or more correctly, an inverse histamine agonist) of the alkylamine class. It competes with histamine for the normal H₁-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies. L-asparagine에 대한 Pharmacology 정보 A non-essential amino acid. Asparagine is critical for the production of the body's proteins, enzymes and muscle tissue. Supplements of this amino acid are claimed to balance nervous system function. Neostigmine에 대한 Pharmacology 정보 Neostigmine is a cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike physostigmine, does not cross the blood-brain barrier. Pyridoxine에 대한 Pharmacology 정보 Vitamin B6 (pyridoxine) is a water-soluble vitamin used in the prophylaxis and treatment of vitamin B6 deficiency and peripheral neuropathy in those receiving isoniazid (isonicotinic acid hydrazide, INH). Vitamin B6 has been found to lower systolic and diastolic blood pressure in a small group of subjects with essential hypertension. Hypertension is another risk factor for atherosclerosis and coronary heart disease. Another study showed pyridoxine hydrochloride to inhibit ADP- or epinephrine-induced platelet aggregation and to lower total cholesterol levels and increase HDL-cholesterol levels, again in a small group of subjects. Vitamin B6, in the form of pyridoxal 5'-phosphate, was found to protect vascular endothelial cells in culture from injury by activated platelets. Endothelial injury and dysfunction are critical initiating events in the pathogenesis of atherosclerosis. Human studies have demonstrated that vitamin B6 deficiency affects cellular and humoral responses of the immune system. Vitamin B6 deficiency results in altered lymphocyte differentiation and maturation, reduced delayed-type hypersensitivity (DTH) responses, impaired antibody production, decreased lymphocyte proliferation and decreased interleukin (IL)-2 production, among other immunologic activities.
Metabolism	Chlorpheniramine에 대한 Metabolism 정보 # Phase_1_Metabolizing_Enzyme:Cytochrome P450 3A4 (CYP3A4)Cytochrome P450 2D6 (CYP2D6) L-asparagine에 대한 Metabolism 정보 # Phase_1_Metabolizing_Enzyme:Not Available Neostigmine에 대한 Metabolism 정보 # Phase_1_Metabolizing_Enzyme:Cholinesterase Pyridoxine에 대한 Metabolism 정보 # Phase_1_Metabolizing_Enzyme:Methylenetetrahydrofolate reductase
Absorption	Chlorpheniramine에 대한 Absorption 정보 Well absorbed in the gastrointestinal tract. Neostigmine에 대한 Absorption 정보 Neostigmine bromide is poorly absorbed from the gastrointestinal tract following oral administration Pyridoxine에 대한 Absorption 정보 The B vitamins are readily absorbed from the gastrointestinal tract, except in malabsorption syndromes. Pyridoxine is absorbed mainly in the jejunum.
Toxicity	Chlorpheniramine에 대한 Toxicity 정보 LD₅₀ = 306 mg/kg in humans, mild reproductive toxin to women of childbearing age. Neostigmine에 대한 Toxicity 정보 Overdosage of Neostigmine can cause cholinergic crisis, which is characterized by increasing muscle weakness, and through involvement of the muscles of respiration, may result in death. The LD 50 of neostigmine methylsulfate in mice is 0.3 ± 0.02 mg/kg intravenously, 0.54 ± 0.03 mg/kg subcutaneously, and 0.395 ± 0.025 mg/kg intramuscularly; in rats the LD 50 is 0.315 ± 0.019 mg/kg intravenously, 0.445 ± 0.032 mg/kg subcutaneously, and 0.423 ± 0.032 mg/kg intramuscularly. Pyridoxine에 대한 Toxicity 정보 Oral Rat LD₅₀ = 4 gm/kg. Toxic effects include convulsions, dyspnea, hypermotility, diarrhea, ataxia and muscle weakness.
Drug Interactions	Chlorpheniramine에 대한 Drug_Interactions 정보 Donepezil Possible antagonism of actionGalantamine Possible antagonism of actionRivastigmine Possible antagonism of actionEthotoin The antihistamine increases the effect of hydantoinFosphenytoin The antihistamine increases the effect of hydantoinMephenytoin The antihistamine increases the effect of hydantoinPhenytoin The antihistamine increases the effect of hydantoin Neostigmine에 대한 Drug_Interactions 정보 Not Available Pyridoxine에 대한 Drug_Interactions 정보 Not Available
CYP450 Drug Interaction	[CYP450 Table직접조회] Chlorpheniramine에 대한 P450 table SUBSTRATES CYP 2D6 Beta Blockers: S-metoprolol propafenone timolol Antidepressants: amitriptyline clomipramine desipramine imipramine paroxetine Antipsychotics: haloperidol risperidone thioridazine aripiprazole codeine dextromethorphan duloxetine flecainide mexiletine ondansetron tamoxifen tramadol venlafaxine INHIBITORS CYP 2D6 amiodarone buproprion chlorpheniramine cimetidine clomipramine duloxetine fluoxetine haloperidol methadone mibefradil paroxetine quinidine ritonavir INDUCERS CYP 2D6 N/A
Food Interaction	Chlorpheniramine에 대한 Food Interaction 정보 Take with food.Avoid alcohol.
Drug Target	[Drug Target]
Description	Chlorpheniramine에 대한 Description 정보 A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. [PubChem] L-asparagine에 대한 Description 정보 A non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue. It is biosynthesized from aspartic acid and ammonia by asparagine synthetase. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed) Neostigmine에 대한 Description 정보 A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike physostigmine, does not cross the blood-brain barrier. [PubChem] Pyridoxine에 대한 Description 정보 The 4-methanol form of vitamin B 6 which is converted to pyridoxal phosphate which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990). [PubChem]
Dosage Form	Chlorpheniramine에 대한 Dosage_Form 정보 Syrup OralTablet OralTablet, extended release Oral Neostigmine에 대한 Dosage_Form 정보 Liquid IntramuscularLiquid IntravenousTablet Oral Pyridoxine에 대한 Dosage_Form 정보 Liquid IntramuscularSolution IntramuscularSolution / drops OralTablet Oral
Drug Category	Chlorpheniramine에 대한 Drug_Category 정보 Anti-Allergic AgentsAntihistaminesAntipruriticsHistamine H1 Antagonists L-asparagine에 대한 Drug_Category 정보 Dietary supplementMicronutrientNon-Essential Amino Acids Neostigmine에 대한 Drug_Category 정보 Cholinesterase InhibitorsParasympathomimetics Pyridoxine에 대한 Drug_Category 정보 Anti-inflammatory AgentsEssential VitaminVitamin B ComplexVitamins (Vitamin B Complex)
Smiles String Canonical	Chlorpheniramine에 대한 Smiles_String_canonical 정보 CN(C)CCC(C1=CC=C(Cl)C=C1)C1=CC=CC=N1 L-asparagine에 대한 Smiles_String_canonical 정보 NC(CC(N)=O)C(O)=O Neostigmine에 대한 Smiles_String_canonical 정보 CN(C)C(=O)OC1=CC(=CC=C1)[N+](C)(C)C Pyridoxine에 대한 Smiles_String_canonical 정보 CC1=NC=C(CO)C(CO)=C1O
Smiles String Isomeric	Chlorpheniramine에 대한 Smiles_String_isomeric 정보 CN(C)CC[C@H](C1=CC=C(Cl)C=C1)C1=CC=CC=N1 L-asparagine에 대한 Smiles_String_isomeric 정보 N[C@@H](CC(N)=O)C(O)=O Neostigmine에 대한 Smiles_String_isomeric 정보 CN(C)C(=O)OC1=CC(=CC=C1)[N+](C)(C)C Pyridoxine에 대한 Smiles_String_isomeric 정보 CC1=NC=C(CO)C(CO)=C1O
InChI Identifier	Chlorpheniramine에 대한 InChI_Identifier 정보 InChI=1/C16H19ClN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3 L-asparagine에 대한 InChI_Identifier 정보 InChI=1/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1/f/h8H,6H2 Neostigmine에 대한 InChI_Identifier 정보 InChI=1/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1 Pyridoxine에 대한 InChI_Identifier 정보 InChI=1/C8H11NO3/c1-5-8(12)7(4-11)6(3-10)2-9-5/h2,10-12H,3-4H2,1H3
Chemical IUPAC Name	Chlorpheniramine에 대한 Chemical_IUPAC_Name 정보 3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine L-asparagine에 대한 Chemical_IUPAC_Name 정보 (2S)-2,4-diamino-4-oxobutanoic acid Neostigmine에 대한 Chemical_IUPAC_Name 정보 [3-(dimethylcarbamoyloxy)phenyl]-trimethylazanium Pyridoxine에 대한 Chemical_IUPAC_Name 정보 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol
Drug-Induced Toxicity Related Proteins	MALEATE 의 Drug-Induced Toxicity Related Protein정보 Replated Protein:Intercellular adhesion molecule 1 Drug:maleate Toxicity:hepatic injury. [바로가기]

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